Managing drug-drug interactions with boceprevir and telaprevir
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چکیده
منابع مشابه
Managing Drug-Drug Interactions With Boceprevir and Telaprevir
The treatment of chronic hepatitis C virus (HCV) genotype 1 infection has been revolutionized by the introduction of direct-acting antiviral (DAA) agents (boceprevir and telaprevir) in combination with peginterferon and ribavirin. Although improved antiviral efficacy and shorter durations of therapy are anticipated, there are also potentially severe drug-drug interactions involving protease inh...
متن کاملA review of drug interactions with boceprevir and telaprevir: implications for HIV and transplant patients.
PURPOSE Chronic hepatitis C virus (HCV) is a major problem affecting up to 170 million people worldwide. Two protease inhibitors have recently been approved that will revolutionize treatment. Our objective was to summarize and evaluate the literature pertaining to the pharmacokinetics of boceprevir and telaprevir, in order to provide clinicians with insight into the management of actual and pot...
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Telaprevir is an inhibitor of the HCV NS3/4A protease. When used in combination with pegylated interferon and ribavirin, telaprevir has demonstrated a substantial increase in sustained virological response compared with pegylated interferon and ribavirin used alone. Telaprevir has good oral bioavailability, which is enhanced when administered with food. Telaprevir is extensively metabolized and...
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Introduction A drug interaction occurs when one drug alters the pharmacological effect (enhanced or decreased) of another drug. In human medicine there are several resources available to screen for drug interactions, and there are specific guidelines and agencies to report suspected drug interactions to. In veterinary medicine screening, monitoring, and reporting of drug interactions are rarely...
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Systemic drugs have been used widely in the treatment of many skin diseases. Although dermatologists are familiar with the guidelines of selecting appropriate patients and prescribing systemic drugs, their knowledge about the side effects and significant interactions of systemic drugs used in dermatology is more limited. So a short review on important drug interactions seems to be useful. Some ...
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ژورنال
عنوان ژورنال: Clinical Liver Disease
سال: 2012
ISSN: 2046-2484
DOI: 10.1002/cld.10